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Testosterone 101: Understanding the Key Role of Testosterone

Testosterone 101 Guide

Testosterone is shrouded in misconceptions. Although it’s “the male sex hormone” researchers still do not fully understand its role in erectile function in men.

On the other hand, women also have testosterone, and the hormone appears to be equally important for their sexual health and overall well-being. That is why testosterone problems can affect both genders.

For example, obesity can lead to abnormalities in both men and women. Obese men usually suffer from low T, while obese women may be producing too much testosterone and develop symptoms of hyperandrogenism.

If you have any complaints that could be related to your T levels, make sure to consult with a medical specialist. Keep reading to discover the most important information about the role of T in your body, related health problems, and their treatment.

What does testosterone do?

Testosterone is a steroid hormone with anabolic and androgenic effects. It produces these effects by binding to the androgen receptors found in most of your tissues, including muscle, bone, skin, and reproductive organs.

In both men and women, the anabolic effects of T help maintain bone density and muscle mass. Besides, its androgenic effects stimulate the development of secondary sexual characteristics during puberty, such as pubic and axillary hair growth.

Furthermore, the hormone regulates sexual desire and mood in both genders.

In men, T also stimulates the development of the male reproductive system and the growth and maturation of spermatozoids. The hormone is produced by the testicles and, to a smaller extent, by the adrenal glands.

In women, T is mainly produced by the adrenal glands but also by the ovaries. The placenta can also produce testosterone during pregnancy.

How do T levels change with age?

Either too high or too low T levels can lead to health problems in both genders. That’s why it’s essential to maintain your testosterone levels in an optimal range.

For adult men, this range is between 300-1000 ng/dL, measured in the morning when the natural synthesis is at its peak. Women have about 20 times lower T levels or about 8-60 ng/dL.

Testosterone levels peak during puberty for both men and women. In this period, it leads to sexual maturation in men and the development of specific axillary and pubic hair in both genders.

Testosterone levels in man body

Once you are past your 30s, T levels inevitably begin to decline. Yet, the decline in women is much slower than in men and may become noticeable only after menopause.

As a rule of thumb, T levels in aging men are 1-2% lower for every year past their 30s. Thus, men in their 80s may end up with only 50% of the T levels in their 30s. If these levels drop under 300 ng/dL, this may also lead to symptoms of low T.

What causes low T?

The most common testosterone abnormality in men is hypogonadism. It is a condition that involves low T levels and symptoms.

It may occur due to problems with the testicles or the pituitary gland. Normally, the pituitary gland produces gonadotropic hormones, which stimulate and regulate the function of the testes.

If the testicles can’t produce adequate amounts of testosterone even under a normal stimulus, this leads to primary hypogonadism.

Causes of primary hypogonadism include:

  • Damage due to tumors, surgery, infections, torsion, chemotherapy, or radiation
  • Testicular atrophy
  • Klinefelter’s syndrome
  • Cryptorchidism
  • Varicocele

Testicular atrophy may occur due to a lack of stimulus from the pituitary gland, which is defined as secondary hypogonadism. Causes may include:

  • Kallmann syndrome
  • Pituitary damage
  • Long-term therapy with glucocorticoids
  • Drug abuse with opioids and/or anabolic steroids

T levels may drop below physiological ranges as you age, leading to symptoms and late-onset hypogonadism in some individuals. Obesity in men can also lead to low T levels.

However, studies suggest that the condition primarily affects total T levels rather than free T levels and is reversible with weight loss.

On the other hand, supraphysiological T levels in men are much rarer and can occur either due to hormone-producing tumors or anabolic steroid abuse.

In women, high T levels may occur as a consequence of various endocrinological problems such as:

  • Hyperinsulinemia
  • Hypothyroidism
  • Congenital adrenal hyperplasia (CAH)
  • Cushing’s syndrome

Hyperinsulinemia is the most common cause, which leads to the development of conditions such as polycystic ovary syndrome (PCOS) and hyperthecosis.

According to studies, the excess of insulin stimulates T production in the ovaries and lowers the levels of serum proteins that normally bind and inactivate testosterone.

In addition, high T in women may also occur due to hormone-secreting adrenal tumors.

Low T in women usually occurs after menopause due to the declining function of the ovaries. It can also occur due to the surgical removal of the ovaries, pituitary dysfunction, or long-term contraceptive therapy.

Symptoms of low and high T

The most common symptoms of hypogonadism in men include chronic fatigue, low libido, depressed mood, loss of muscle mass, and increased body fat.

10 symptoms of low testosterone in menPatients often report falling asleep right after dinner due to exhaustion and extreme sleepiness. In severe cases, you may experience erectile dysfunction, loss of pubic and facial hair.

High testosterone levels that significantly exceed physiological references in men may also lead to complaints. For example, individuals who abuse anabolic steroids may experience oily skin, acne, increased red blood cell count, water retention, high blood pressure, and cardiovascular problems.

Women with abnormally high T may develop masculine characteristics such as increased body and facial hair (hirsutism), deeper voice, male-pattern hair loss, enlarged clitoris, acne, and oily skin. This combination of symptoms is called virilization.

In addition, women with high T suffer from irregular or absent menstruation and infertility.

Women’s lack of T has more subtle and unspecific symptoms such as low libido, vaginal dryness, and depressed mood. These symptoms are also related to the decline of estrogen, which occurs during menopause.

The only way to know the exact cause of your symptoms is to visit a medical doctor, specifically an endocrinologist.

How to test T levels?

The initial diagnosis of high or low T in men or women begins with a doctor’s consultation involving medical history and physical exam.

Diagnosis of high or low TIf your physician suspects that your complaints may be related to abnormalities in your T levels, then they will assign you specific tests.

According to the American Urological Association, low T in men is diagnosed after measuring T levels in serum. The test must be performed twice in two separate mornings to confirm the diagnosis.

If both measurements reveal total T levels under 300 ng/d and you have symptoms, then your doctor will diagnose you with hypogonadism.

There are also modern methods for testing T levels, such as at-home testosterone tests, which are growing in popularity thanks to their convenience and affordability. Yet, your doctor can’t diagnose you with low T using at-home tests for testosterone.

Such tests measure T levels in saliva rather than serum, which is not accurate enough according to research. Instead, you should visit a licensed laboratory to receive reliable testosterone testing.

Another method that’s growing in popularity is the ratio between the fingers of your hand.

Preliminary studies suggest that the ratio between the digits of your hand, more specifically your index and ring finger (2D:4D ratio), depends on your intrauterine exposure to testosterone and estrogen.

However, the 2D:4D ratio cannot be used for T levels evaluation in adults.

The American Association of Clinical Endocrinologists suggests that women should be diagnosed with high T only after thorough medical examinations and several hormonal tests. The tests include testosterone, luteinizing hormone, follicle-stimulating hormone, prolactin, insulin, and others.

Treatment options

Once your doctor has established the cause of your complaints, they will assign you appropriate treatment via medical prescription.

Currently, the most effective treatment for men with hypogonadism, according to the international guidelines, is the administration of exogenous testosterone. The aim of the therapy is to restore serum T levels within physiological limits.Forms of testosterone

Testosterone Replacement Therapy (TRT) includes various forms of testosterone administration, including intramuscular injections, implants, pills, and transdermal gels.

Physicians and most patients prefer testosterone injections as a method for TRT since it is the most affordable and reliable. It is easily dosed, which allows for faster correction of serum T levels and quicker symptom management.

Legal TRT can be purchased from licensed pharmacies only via medical prescription

TRT should be avoided by patients who plan to father children and desire to remain fertile. Also, there are several medical contraindications such as:

  • Severe lower urinary tract problems
  • Severe sleep apnea
  • History of breast or prostate cancer
  • A cardiovascular incident in the last 6 months
  • Elevated hematocrit and/or thrombocytes

In women with high T, the most effective therapy depends on the underlying condition. Usually, it involves medication treatment alone or in combination with lifestyle changes.

The most commonly prescribed medication is low-dose estrogen-based contraceptives. Evidence suggests that they can help lower T levels in PCOS, CAH, and postmenopausal women.

Contraceptives with progestogens should be avoided since they can activate the androgen receptors and worsen the symptoms.

What to expect from treatment?

If you are receiving TRT, your doctor should monitor the safety and effectiveness of your treatment via regular checkups every 3-6 months and then annually after your first year of therapy.

The timeline of the first benefits depends on the form of TRT. Testosterone injections will improve libido, erectile function, and mood symptoms as soon as the 3rd week after starting treatment.

It takes at least 8-12 weeks until there is any improvement in body composition and physical performance, and at least 24 weeks for reduced risk of bone fractures.

TRT may lead to adverse reactions, so you should visit a qualified specialist. Your doctor will discuss the risks and benefits of TRT and offer you the most suitable treatment form.

Besides, they will ensure that you do not have any contraindications for TRT and will perform regular tests during your visits and correct your dosage if needed. By reducing the dose of TRT, side effects can be successfully avoided in most patients.

Natural options to balance T levels

How to increase testosterone in men

Men looking to boost their T levels naturally may benefit from lifestyle changes such as improved sleep and increased physical activity.

  • Sufficient Sleep. Research has shown that sleeping less than 7 hours per night reduces T levels by 15% for each hour of missed sleep.
  • Regular physical activity. Physical exercises which stimulate muscle hypertrophy, such as resistance training and lifting weight, also appear effective in increasing T levels in men.
  • Optimal Body Weight. Both too high and too low body fat levels are linked to low T. You should aim for 8-19% body fat as a man. To correct your body fat percentage, you should either increase or decrease your caloric intake.
  • Healthy Diet. The exact type of nutrients also matters – it is vital for your testosterone production to consume adequate amounts of dietary fats and carbohydrates. For example, olive oil is both healthy and a testosterone-boosting source of fats.
  • Dietary Supplements. Men who are deficient in vitamin D or zinc may also experience T improvement with supplementation.

However, most dietary supplements labeled as testosterone boosters are rather ineffective in increasing the natural T synthesis. In fact, research suggests that about 10% of the most popular ingredients in such supplements may actually reduce T levels.

Dehydroepiandrosterone (DHEA) is the only ingredient with solid scientific support as a testosterone booster, Yet, DHEA supplementation can lead to a significant increase in estrogen levels as well.

How to lower T levels in women

Women with high T levels due to PCOS may also benefit from lifestyle changes.

  • Optimal Body Weight. Weight loss is recommended as the first step in those who are also overweight or obese, and studies report significant improvements in PCOS symptoms after 5-10% weight reduction.
  • Regular physical activity. According to a large amount of research, increasing physical activity is a great strategy to boost weight loss and improve insulin resistance in those patients.
  • Dietary Supplements. Studies report that supplementing with inositol is also effective in lowering insulin levels and improving fertility in patients with PCOS. Natural food sources of inositol are whole grains and citrus fruits.